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Ubiquitin C-terminal hydrolase 1 is increased in migraine attack

M Atescelik1, M Yilmaz1

  • 1Department of Medicine, Firat University of Emergency Medicine, Yunus Emre road, 23200 Elazig, Turkey.

Revue Neurologique
|September 26, 2022
PubMed

Insights

Serum levels of Ubiquitin C-terminal hydrolase 1 (UCHL1) increase during migraine attacks. UCHL1 levels can help assess migraine severity and treatment effectiveness.

Area of Science:

  • Neurology
  • Biochemistry

Background:

  • Migraine is a common neurological disorder.
  • Biomarkers for migraine diagnosis and severity assessment are needed.

Purpose of the Study:

  • To investigate serum Ubiquitin C-terminal hydrolase 1 (UCHL1) levels in patients experiencing migraine attacks.
  • To evaluate changes in UCHL1 levels after treatment.

Main Methods:

  • Serum samples were collected from 43 migraine patients and 30 healthy controls.
  • Patients were grouped as: during migraine attack, 4 hours post-treatment, and healthy controls.
  • Levels of UCHL1 and Visual Analogue Scale (VAS) scores were analyzed.

Main Results:

  • Significantly higher UCHL1 levels were observed during migraine attacks compared to post-treatment and healthy controls (P<0.001).
  • A positive correlation was found between VAS scores and UCHL1 levels before treatment (r=0.884, P<0.001).
  • Significant differences in UCHL1 levels were found between all study groups.

Conclusions:

  • Serum UCHL1 levels are elevated during acute migraine attacks.
  • UCHL1 may serve as a potential biomarker for migraine severity and treatment response.
Abstract

Keywords:
MigraineUCHL1Ubiquitin C-terminal hydrolase-1VAS

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