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[Changes in the respiratory function in Gougerot-Sjögren syndrome]
Revue De Pneumologie Clinique
|January 1, 1987
Summary
Sjögren's syndrome can cause lung issues, including airway obstruction and reduced lung diffusing capacity. Secondary Sjögren's syndrome, especially with rheumatoid arthritis, shows greater lung function impairment correlating with disease duration.
Area of Science:
- Pulmonary Medicine
- Rheumatology
- Immunology
Context:
- Sjögren's syndrome (SGS) is a chronic autoimmune disease primarily affecting exocrine glands.
- Pulmonary complications are increasingly recognized in SGS, impacting patient morbidity.
- Limited data exists on the specific patterns and severity of lung function abnormalities in SGS.
Purpose:
- To comprehensively assess lung function in patients with Sjögren's syndrome.
- To investigate differences in lung function between primary and secondary SGS.
- To explore correlations between lung function, disease duration, and associated connective tissue diseases.
Summary:
- Lung function tests including spirometry, lung resistance, and diffusing capacity were performed on 36 SGS patients.
- Results indicated distal airway obstruction and decreased lung diffusing capacity, suggesting alveolar-capillary membrane dysfunction.
- Secondary SGS (SGS II), particularly with rheumatoid arthritis, exhibited more significant lung function alterations, linked to disease duration and ventilatory mechanics.
Impact:
- Highlights the significant impact of Sjögren's syndrome on lung function, extending beyond typical sicca symptoms.
- Identifies specific patterns of lung impairment (airway obstruction, reduced diffusion) relevant for clinical monitoring.
- Suggests closer pulmonary surveillance for SGS patients, especially those with secondary disease and rheumatoid arthritis, due to potential for greater lung damage.