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Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
Published on: May 27, 2011
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HIV T-cell immunogen design and delivery.
Christian Brander1,2,3, Dennis Hartigan-O'Connor4,5,6
1Irsicaixa - AIDS Research Institute, Badalona.
Current Opinion in HIV and AIDS
|September 27, 2022
Summary
Advanced immunogen designs targeting T-cell responses are crucial for controlling HIV infection. Specificity in T-cell immunogens is key for effective therapeutic vaccines, though design alignment remains a challenge.
Area of Science:
- Immunology
- Vaccinology
- Virology
Background:
- T-cell responses vary in effectiveness against HIV, with specific epitope responses linked to better infection control.
- This has driven the creation of diverse immunogen sequences for HIV vaccine development.
Purpose of the Study:
- To review advanced T-cell immunogen designs for therapeutic HIV vaccines nearing clinical trials.
- To highlight the significance of immunogen delivery methods and the lack of standardization in current designs.
Main Methods:
- Review of advanced immunogen designs in preclinical and clinical studies.
- Focus on T-cell immunogens for therapeutic applications.
Main Results:
- Few immunogen designs have shown significant promise to date.
- Emerging data underscore the critical role of specificity in effective in vivo antiviral activity.
Conclusions:
- The specificity of induced T-cell responses is vital for effective control of HIV infection.
- Lack of alignment between immunogen designs and vaccine regimens impedes progress in therapeutic vaccine development.
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