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Amyloid Fibrils

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...

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Updated: Aug 27, 2025

A Protocol for the Production of Gliadin-cyanoacrylate Nanoparticles for Hydrophilic Coating

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Published on: July 8, 2016

Functional Coating from Amyloid Superwetting Films.

Tonghui Jin¹, Mohammad Peydayesh¹, Mingqin Li¹

¹Department of Health Sciences and Technology, ETH Zurich, Zurich, 8092, Switzerland.

Advanced Materials (Deerfield Beach, Fla.)

|September 27, 2022

Summary

This summary is machine-generated.

Researchers developed a universal method using amyloid fibrils to create multifunctional surfaces. These surfaces offer superwettability, enhanced separation capabilities, and serve as platforms for biocatalysis, expanding bio-based applications.

Keywords:

amyloid fibrils antifogging antifouling enzyme immobilization oil/water separation β-lactoglobulin

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Area of Science:

Materials Science
Biotechnology
Surface Chemistry

Background:

Surface hydrophilicity tailoring is crucial but often limited to wettability.
Existing methods lack multifunctional capabilities for diverse applications.

Purpose of the Study:

To extend surface functionalization beyond wettability using amyloid fibrils.
To demonstrate multifunctional properties including separation, antifouling, and biocatalysis.

Main Methods:

Universal coating of amyloid fibrils onto various substrates (fabrics, metals, polymers, glass).
Evaluation of oil/water separation, emulsion separation, antifouling, and antifogging performance.
Immobilization of enzymes (laccase) for biocatalytic activity assessment.

Main Results:

Amyloid fibril coatings impart superwettability and excellent performance in oil/water and emulsion separation.
Surfaces exhibited effective antifouling and antifogging properties.
Biocompatible coatings facilitated enzyme immobilization for biocatalysis, demonstrated by ABTS oxidation and dye degradation.

Conclusions:

Amyloid fibrils provide a universal platform for creating multifunctional surfaces with tailored properties.
This approach enables bio-based applications in separation, antifouling, and biocatalysis.
Fibrous protein templates offer a novel strategy for surface modification and expanded functionality.