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Peripheral ulcerative keratitis due to systemic diseases
1Department of Ophthalmology.
Current Opinion in Ophthalmology
|September 27, 2022
Summary
Peripheral ulcerative keratitis (PUK) is a serious eye condition linked to systemic diseases like rheumatoid arthritis. Early, aggressive treatment is crucial to prevent vision loss and other severe outcomes.
Area of Science:
- Ophthalmology
- Rheumatology
- Systemic Autoimmune Diseases
Background:
- Peripheral ulcerative keratitis (PUK) is a sight-threatening condition characterized by peripheral corneal thinning and inflammation.
- PUK is strongly associated with systemic autoimmune and connective tissue diseases.
Purpose of the Study:
- To review the evaluation and management of peripheral ulcerative keratitis (PUK).
- To emphasize the importance of identifying and treating associated systemic diseases in PUK patients.
Main Methods:
- Literature review focusing on PUK diagnosis and treatment.
- Analysis of the relationship between PUK and systemic inflammatory conditions.
Main Results:
- PUK presents as peripheral corneal thinning, epithelial defects, and infiltrate.
- High association with rheumatoid arthritis, granulomatosis with polyangiitis, and systemic lupus erythematosus.
- Untreated PUK can lead to vision loss and increased mortality risk.
Conclusions:
- Effective PUK management requires multidisciplinary collaboration between ophthalmologists and rheumatologists.
- Early, aggressive, steroid-sparing therapies are recommended for PUK secondary to systemic disease.
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