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Related Concept Videos

Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

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Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
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Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Peripheral Artery Disease IV: Nursing Management01:26

Peripheral Artery Disease IV: Nursing Management

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 The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
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Chronic Kidney Disease II: Clinical Manifestations01:24

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Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
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Peptic Ulcer Disease I: Introduction01:30

Peptic Ulcer Disease I: Introduction

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Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
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Chronic Bowel Disorders: Introduction01:17

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Peripheral ulcerative keratitis due to systemic diseases.

Amol A Sura1, Rex M McCallum2

  • 1Department of Ophthalmology.

Current Opinion in Ophthalmology
|September 27, 2022
PubMed
Summary
This summary is machine-generated.

Peripheral ulcerative keratitis (PUK) is a serious eye condition linked to systemic diseases like rheumatoid arthritis. Early, aggressive treatment is crucial to prevent vision loss and other severe outcomes.

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Area of Science:

  • Ophthalmology
  • Rheumatology
  • Systemic Autoimmune Diseases

Background:

  • Peripheral ulcerative keratitis (PUK) is a sight-threatening condition characterized by peripheral corneal thinning and inflammation.
  • PUK is strongly associated with systemic autoimmune and connective tissue diseases.

Purpose of the Study:

  • To review the evaluation and management of peripheral ulcerative keratitis (PUK).
  • To emphasize the importance of identifying and treating associated systemic diseases in PUK patients.

Main Methods:

  • Literature review focusing on PUK diagnosis and treatment.
  • Analysis of the relationship between PUK and systemic inflammatory conditions.

Main Results:

  • PUK presents as peripheral corneal thinning, epithelial defects, and infiltrate.
  • High association with rheumatoid arthritis, granulomatosis with polyangiitis, and systemic lupus erythematosus.
  • Untreated PUK can lead to vision loss and increased mortality risk.

Conclusions:

  • Effective PUK management requires multidisciplinary collaboration between ophthalmologists and rheumatologists.
  • Early, aggressive, steroid-sparing therapies are recommended for PUK secondary to systemic disease.