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Updated: Aug 27, 2025

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Published on: May 7, 2013
Nano-Calcium Carbonate Affect the Respiratory and Function Through Inducing Oxidative Stress: A Cross-sectional Study
1From the Department of Health Toxicology, School of Public Health, Shanxi Medical University, Taiyuan, China (Ms Lyu, Ms Zhang, Ms Liu, Dr Zhang, Ms Tian, Ms Zhang, Mr Hu, Ms Feng, Ms Qian, Mr Jiang, Ms Zhang, Ms Ma, Dr Zheng, Dr Qiu); Department of Biochemistry and Molecular Biology, School of Preclinical Medicine, Shanxi Medical University, Taiyuan, China (Ms Lyu); Department of Public Health and Preventive Medicine, Changzhi Medical College, Changzhi, China (Dr Zheng); and Institute of Urban Safety and Environmental Science, Beijing Academy of Science and Technology, Beijing, China (Dr Tang).
Objective:
The aim of the study is to investigate whether nano-calcium carbonate (nano-CaCO 3 ) occupational exposure could induce adverse health effects in workers.
Methods:
A cross-sectional study was conducted in a nano-CaCO 3 manufacturing plant in China. Then, we have studied the dynamic distribution of nano-CaCO 3 in nude mice and examined the oxidative damage biomarkers of subchronic administrated nano-CaCO 3 on Sprague-Dawley rats.
Results:
The forced vital capacity (%) and the ratio of FEV1 to FVC is the rate of one second of workers were significantly decreased than unexposed individuals. Dynamic imaging in mice of fluorescence labeled nano-CaCO 3 showed relatively high uptake and slow washout in lung. Similar to population data, the decline in serum glutathione level and elevation in serum MDA were observed in nano-CaCO 3 -infected Sprague-Dawley rats.
Conclusions:
We found that nano-CaCO 3 exposure may result in the poor pulmonary function in workers and lead to the changes of oxidative stress indexes.
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