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Related Experiment Video

Updated: Aug 27, 2025

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snoDB 2.0: an enhanced interactive database, specializing in human snoRNAs.

Danny Bergeron1, Hermes Paraqindes2,3,4, Étienne Fafard-Couture1

  • 1Département de biochimie et génomique fonctionnelle, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, Québec J1E 4K8, Canada.

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snoDB 2.0 is an updated database for human small nucleolar RNAs (snoRNAs), now including ribosomal RNA (rRNA) modifications. This resource aids in exploring snoRNA functions and their regulatory roles.

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Area of Science:

  • Molecular Biology
  • Genomics
  • Bioinformatics

Background:

  • Small nucleolar RNAs (snoRNAs) are crucial non-coding RNAs involved in various cellular processes.
  • Understanding snoRNA function requires comprehensive data on their features, targets, and interactions.
  • Existing databases may lack integrated information on snoRNA-guided modifications.

Purpose of the Study:

  • To present snoDB 2.0, an enhanced interactive database for human snoRNAs.
  • To incorporate a new section detailing ribosomal RNA (rRNA) chemical modifications guided by snoRNAs.
  • To provide expanded data layers for deeper functional analysis of snoRNAs.

Main Methods:

  • Database development and integration of diverse data types.
  • Curation of information on snoRNA features, genomic locations, and targets.
  • Inclusion of data on rRNA modification levels and snoRNA-protein interactions.

Main Results:

  • snoDB 2.0 offers updated information on snoRNA features, conservation, and abundance.
  • A new comprehensive section on snoRNA-guided rRNA modifications is available.
  • Expanded data includes snoRNA motifs, secondary structures, and expression profiles across tissues.

Conclusions:

  • snoDB 2.0 serves as a centralized resource for snoRNA research.
  • The database facilitates the study of snoRNA functions, including rRNA modification.
  • It supports the investigation of snoRNA biology and potential regulatory roles.