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Apparent diffusion coefficient for assessing Crohn's disease activity: a meta-analysis
Maximilian Thormann1, Bohdan Melekh2, Caroline Bär2
1Department of Radiology and Nuclear Medicine, University of Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany. maximilian.thormann@med.ovgu.de.
Apparent diffusion coefficient (ADC) in Crohn's disease correlates inversely with disease activity scores like CDAI, MaRIA, and SES-CD. However, ADC is limited in assessing fibrotic changes and cannot reflect systemic inflammation.
Area of Science:
- Gastroenterology
- Radiology
- Medical Imaging
Background:
- Crohn's disease (CD) is a chronic inflammatory bowel disease.
- Accurate assessment of disease activity and complications is crucial for effective management.
- Apparent diffusion coefficient (ADC) is an emerging imaging biomarker.
Approach:
- A systematic review and meta-analysis was conducted on studies published up to May 2021.
- Data from 21 studies involving 1053 patients were analyzed.
- Spearman's correlation coefficient was used to assess associations between ADC and various CD activity parameters.
Key Points:
- Apparent diffusion coefficient (ADC) demonstrated strong inverse correlations with Crohn's Disease Activity Index (CDAI), MaRIA, and SES-CD scores.
- ADC effectively reflects acute inflammatory activity in Crohn's disease.
- The utility of ADC in evaluating fibrotic changes in the bowel wall is limited.
Conclusions:
- ADC is a valuable tool for assessing acute inflammatory activity in Crohn's disease.
- ADC shows significant inverse relationships with key clinical and endoscopic scoring systems.
- Further research is needed to explore the role of ADC in fibrotic complications of Crohn's disease.
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