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Impaired left ventricular deformation and ventricular-arterial coupling in post-COVID-19: association with autonomic

Evangelos Oikonomou1,2, Stamatios Lampsas3, Panagiotis Theofilis4

  • 13rd Department of Cardiology, National and Kapodistrian University of Athens, Medical School, Sotiria Chest Disease Hospital, Mesogeion 152, 11527, Athens, Greece. boikono@gmail.com.

Heart and Vessels
|September 28, 2022
PubMed

Insights

Long COVID-19 syndrome impairs cardiac function and autonomic regulation. Patients show persistent left ventricular dysfunction and aortic stiffness six months post-discharge, indicating a need for ongoing cardiovascular monitoring.

Area of Science:

  • Cardiology
  • Pulmonology
  • Nephrology

Background:

  • Long COVID-19 syndrome presents significant long-term health challenges.
  • Cardiovascular complications are a key concern in post-COVID-19 patients.
  • Understanding the persistent effects on cardiac function is crucial.

Purpose of the Study:

  • To assess longitudinal changes in cardiac function, aortic stiffness, and autonomic regulation in post-COVID-19 patients.
  • To investigate ventricular-arterial coupling (VAC) over time.
  • To identify potential cardiovascular markers associated with Long COVID-19.

Main Methods:

  • Longitudinal study of 34 post-COVID-19 patients up to 6 months post-discharge.
  • Evaluation of left ventricular global longitudinal strain (LV-GLS) and carotid-femoral pulse wave velocity (cf-PWV).
  • Assessment of heart rate variability (SDNN) and calculation of VAC (cf-PWV/LV-GLS).

Main Results:

  • Post-COVID-19 patients exhibited impaired LV-GLS, cf-PWV, SDNN, and VAC at 1 month compared to controls.
  • Improvements were observed at 6 months, but cardiac function and autonomic measures did not normalize.
  • SDNN and VAC showed significant correlations at both 1 and 6 months.

Conclusions:

  • Long COVID-19 is associated with persistent left ventricular dysfunction, autonomic dysregulation, and impaired ventricular-arterial coupling.
  • These cardiovascular abnormalities suggest a link between Long COVID-19 syndrome and ongoing cardiac and vascular impairment.
  • Regular cardiovascular assessment is recommended for post-COVID-19 patients to monitor long-term effects.

Keywords:
Autonomic dysfunctionCOVID-19Global longitudinal strainVentricular-arterial coupling

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