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Metabolic Profiling to Determine Bactericidal or Bacteriostatic Effects of New Natural Products using Isothermal Microcalorimetry
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[A case of pyroglutamic metabolic acidosis after cotreatment by flucloxacillin and paracetamol]

Adlija Desgranges1, Ketty Hu1, Carole Monney Chaubert2

  • 1Service de médecine interne, Établissements hospitaliers du Nord vaudois, Yverdon, 1400 Yverdon-les-Bains.

Revue Medicale Suisse
|September 28, 2022
PubMed

Insights

A 73-year-old man developed metabolic acidosis due to flucloxacillin and paracetamol. Treatment with N-acetylcysteine resolved the condition, highlighting drug interactions in patients with risk factors.

Area of Science:

  • Internal Medicine
  • Clinical Toxicology
  • Pharmacology

Background:

  • A 73-year-old male presented with confusion and dyspnea.
  • The patient was undergoing a six-week course of flucloxacillin for methicillin-susceptible Staphylococcus aureus (MSSA) endocarditis with a complicated knee prosthesis infection.

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