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A nomenclature consensus for nervous system organoids and assembloids.
Sergiu P Pașca1,2, Paola Arlotta3,4, Helen S Bateup5,6,7
1Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA. spasca@stanford.edu.
Nature
|September 28, 2022
Summary
This study proposes a standardized nomenclature for human multicellular models, including organoids and assembloids, derived from stem cells. This framework aims to advance research into nervous system development and disease understanding.
Area of Science:
- Neuroscience
- Developmental Biology
- Stem Cell Research
Background:
- Three-dimensional cellular models from human stem cells or tissue offer insights into nervous system development and disorders.
- Current research faces challenges in communication and standardization.
Purpose of the Study:
- To establish a clear nomenclature for human multicellular models of nervous system development and disease.
- To facilitate scientific communication and public understanding.
Main Methods:
- Review and synthesis of existing terminology.
- Development of a hierarchical classification framework.
Main Results:
- A proposed basic framework for nomenclature is presented.
- Key model types such as organoids, assembloids, and transplants are defined within this framework.
Conclusions:
- Standardized nomenclature is crucial for advancing research on the human nervous system.
- This framework supports consistent communication in the scientific community and public outreach.
