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Hoof wall separation disease: A Review.
1Department of Population Health and Reproduction, School of Veterinary Medicine, University of California-Davis, Davis, CA 95616, USA.
Equine Veterinary Education
|September 29, 2022
Summary
Hoof wall separation disease (HWSD) is a genetic defect in Connemara ponies. Genetic testing identifies carriers, crucial for breeding management to prevent this debilitating hoof condition.
Area of Science:
- Veterinary Genetics
- Equine Pathology
Background:
- Hoof wall separation disease (HWSD) is a genetic disorder affecting Connemara ponies.
- It causes dorsal hoof wall separation, cracking, inflammation, lameness, and laminitis, typically appearing within the first six months of life.
Purpose of the Study:
- To review the clinical presentation, genetic basis, and management of HWSD in Connemara ponies.
- To highlight the importance of genetic testing for disease control.
Main Methods:
- Review of clinical and histopathologic findings.
- Identification of the genetic mutation (c.504_505insC) in the *SERPINB11* gene.
- Estimation of carrier frequency within the Connemara breed.
Main Results:
- HWSD is an autosomal recessive trait caused by a frameshift mutation in *SERPINB11*.
- Carrier frequency in Connemara ponies is estimated at 14.8%; affected ponies are homozygous for the mutation.
- The mutation has not been identified in other breeds.
Conclusions:
- Effective management involves targeted hoof care, special shoeing, and environmental adjustments.
- Genetic testing is mandatory for Connemara pony registrations to control HWSD.
- While no cure exists, early detection and management can mitigate disease severity.
