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Updated: Aug 27, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Good theoretical debate, but insufficient proof of concept
1Internal Medicine Section, Department of Acute Medicine, Basel University Hospital, 4031 Basel, Switzerland rainer_spiegel@hotmail.com rainer.spiegel@usb.chhttps://www.researchgate.net/profile/Rainer-Spiegel.
Abstract:
Bruineberg and colleagues argue that the patellar reflex cannot be modeled sufficiently with a Friston blanket due to counterintuitive sensorimotor boundaries. Although I agree with their theoretical discussion, their model of the patellar reflex is insufficiently based on clinical knowledge. Consequently, this example should not be applied to challenge Friston blankets. I will provide an alternative example.
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