Anesthesia Management for Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Surgery on Short-Term...

Area of Science:

• Anesthesiology
• Surgical Oncology
• Critical Care Medicine

Background:

• Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS+HIPEC) is a complex procedure.
• Optimizing perioperative management is crucial for patient recovery and outcomes.

Purpose of the Study:

• To investigate the impact of anesthesia management on short-term patient outcomes following CRS+HIPEC.
• To identify perioperative factors associated with prolonged hospital stay, ICU stay, and postoperative complications.

Main Methods:

• Retrospective analysis of 833 CRS+HIPEC cases from two institutions.
• Evaluation of perioperative electronic medical records to identify predictive factors for patient outcomes.

Main Results:

• Older age, higher ASA score, male gender, longer anesthesia duration, higher Peritoneal Cancer Index (PCI), and greater intraoperative blood loss were associated with prolonged hospital stay.
• Prolonged ICU stay was linked to older age, higher ASA score, longer anesthesia time, higher PCI, increased fluid administration, lower propofol dosage, higher blood loss, and failed extubation.
• Higher postoperative complications correlated with older age, male gender, longer anesthesia time, higher ASA score, higher PCI, increased opioid dosage, and greater blood loss.

Conclusions:

• Anesthesia management plays a significant role in CRS+HIPEC outcomes.
• Implementation of enhanced recovery after surgery (ERAS) protocols may improve patient outcomes.
• Further prospective randomized studies are needed to confirm these findings.