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Is Vitamin D Deficiency Prothrombotic? A Systematic Review
Isabella Hangaard Rüdiger1, Matilde Kanstrup Andersen1,2, Anna Louise Vestergaard1,2
1Department of Obstetrics and Gynecology, Regional Hospital of Randers, Randers, Denmark.
Seminars in Thrombosis and Hemostasis
|September 29, 2022
Summary
Vitamin D deficiency is linked to thrombotic events, but this review found no definitive evidence of a prothrombotic profile. Further research is needed to clarify the relationship between vitamin D and thrombosis risk.
Area of Science:
- Cardiovascular Medicine
- Endocrinology
- Hematology
Background:
- Observational studies suggest a link between vitamin D deficiency and increased thrombotic events.
- The mechanisms underlying this association remain unclear.
- This review investigates the relationship between vitamin D levels and a prothrombotic state.
Approach:
- A systematic literature search identified 3,214 studies up to December 21, 2021.
- 18 observational and intervention studies met the inclusion criteria.
- The review analyzed parameters of primary and secondary hemostasis, and fibrinolysis.
Key Points:
- Most studies found no significant association between decreased vitamin D and hemostatic parameters.
- Conflicting results were observed regarding thrombin generation, tissue factor pathway inhibitor, and fibrinolysis regulators.
- Some evidence suggests a weak association with decreased tissue type plasminogen activator.
Conclusions:
- This systematic review did not establish a definitive link between vitamin D deficiency and a prothrombotic profile.
- There is insufficient clinical evidence to support or refute an antithrombotic effect of vitamin D.
- High-quality randomized controlled trials are necessary to further investigate this relationship.
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