Related Experiment Videos
[Experimental Salmonella dublin infection in calves]
Veterinarno-Meditsinski Nauki
|January 1, 1987
Summary
Experimental Salmonella Dublin infection in calves showed that higher bacterial doses led to severe clinical signs and organ invasion. Lower doses resulted in minimal symptoms, indicating a dose-dependent response in young cattle.
Area of Science:
- Veterinary Medicine
- Microbiology
- Animal Pathology
Background:
- Salmonella Dublin is a significant pathogen in cattle.
- Understanding dose-dependent effects is crucial for disease management.
Purpose of the Study:
- To investigate the clinical and pathological effects of experimental Salmonella Dublin infection in calves.
- To determine the relationship between bacterial dose and disease severity.
Main Methods:
- Twenty-day-old calves were experimentally infected with Salmonella Dublin.
- Two groups received different doses: 6.10^8 (low) and 2.10^10 to 4.10^10 (high) live bacterial cells.
- Clinical signs, bacterial shedding, and post-mortem organ examination were assessed.
Main Results:
- Calves receiving the higher Salmonella Dublin dose exhibited typical clinical signs and regular bacterial shedding.
- The lower dose group showed minimal clinical symptoms and inconsistent shedding.
- Salmonella Dublin was detected in all parenchymal organs and lymph nodes of infected calves.
- Histopathology revealed inflammatory necrobiotic processes in the liver, lymph node sinus endothelium proliferation, and small intestine inflammation.
Conclusions:
- Higher doses of Salmonella Dublin cause severe clinical disease and systemic organ invasion in calves.
- Lower doses may lead to subclinical infections with less shedding.
- Salmonella Dublin infection induces significant pathological changes in multiple organs and lymph nodes.