[Role of hydatidiform mole in the pathogenesis of choriocarcinoma]

Such pathogenetic patterns of choriocarcinoma (ChC) as development after normal and pathologic gestation are discussed. Clinically-based criteria of vesicular mole progression were established. It was found that 66.4 +/- 4.4% of cases did not need chemotherapy because removal of vesicular mole was invariably followed by cure. Therapy was indicated in 29.2 +/- 4.3% as symptoms continued to increase. Transition of untreated vesicular mole to ChC was recorded in 4.4 +/- 1.9% of cases. Timely adjuvant chemotherapy reduced relative risk of transformation to ChC 17.7 times.