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Published on: February 6, 2021
[COVID-19-associated mucormycosis in ophthalmological practice in the Volgograd region]
V V Ermilov1, A V Smirnov1,2, N A Dorofeev1,2
1Volgograd State Medical University, Volgograd, Russia.
Abstract:
The problem of fungal infections in the era of COVID-19 has acquired special significance. This infection, directly or indirectly, through the use of glucocorticoids and antibiotics in its treatment, as well as poorer self-management of chronic diseases, has led to a wide spread of risk factors for fungal diseases among people who have had a novel coronavirus infection. The article presents two cases of COVID-19-associated mycosis, more related to mucormycosis, which were diagnosed by ophthalmologists in the Volgograd region. In the first case, the severe course of rhino-orbito-cerebral form of mucormycosis required a number of surgical interventions and prolonged treatment in the intensive care unit. In the second case, the patient asked for help without signs of aggravation of the general condition, but with irreversible local manifestations. In both cases, the eyeball was removed. Morphological examination revealed aseptal ribbon hyphae of different diameters, branching mainly at right angles, more typical for fungi of the Mucorales family. Due to the severe consequences of the disease, clinicians, including ophthalmologists, need to be especially alertness in patients with the described symptoms and risk factors in the post-COVID period.
Insights
COVID-19 increases the risk of fungal infections like mucormycosis. Early detection and vigilance by clinicians are crucial for managing these severe post-COVID complications, often requiring enucleation.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Mycology
Background:
- The COVID-19 pandemic has heightened the significance of fungal infections.
- COVID-19 treatment and management increase risk factors for fungal diseases.
- Post-COVID patients exhibit a higher prevalence of fungal infection risk factors.
Purpose of the Study:
- To present two cases of COVID-19-associated mycosis, specifically mucormycosis.
- To highlight the diagnostic role of ophthalmologists in these cases.
- To emphasize the need for clinical alertness in post-COVID patients.
Main Methods:
- Case report of two patients diagnosed with COVID-19-associated mucormycosis.
- Ophthalmological diagnosis and management.
- Morphological examination of fungal hyphae.
Main Results:
- Two cases of rhino-orbito-cerebral mucormycosis linked to COVID-19 were diagnosed.
- One case involved severe disease requiring intensive care and surgery.
- Morphological analysis confirmed Mucorales fungi; both patients underwent enucleation.
Conclusions:
- COVID-19-associated mycosis, particularly mucormycosis, poses severe risks.
- Ophthalmologists play a critical role in diagnosing these post-COVID complications.
- Increased clinical alertness is essential for managing patients with risk factors in the post-COVID period.
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