Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Brain Abscess l: Introduction01:26

Brain Abscess l: Introduction

A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...
Increased Intracranial Pressure ll: Pathophysiology01:29

Increased Intracranial Pressure ll: Pathophysiology

Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins with...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neurologists' Views on the Management of Uncontrolled Epilepsy in Spain: A Preliminary Survey.

Neurology and therapy·2026
Same author

Is achieving higher standards in real-world migraine care feasible with anti-CGRP monoclonal antibodies preventive therapies?: Insights from the EUREkA cohort.

Cephalalgia : an international journal of headache·2026
Same author

Trigeminal Terminal Branch Neuralgias in a Headache Unit: A 15-Year Series.

Journal of pain research·2026
Same author

Long-Term Effectiveness and Persistence Factors of Anti-CGRP Monoclonal Antibodies in Migraine: 2-Year Results From the EUREkA Cohort.

Neurology·2026
Same author

Evaluation of the effectiveness and safety of anti-CGRP monoclonal antibodies in patients with migraine and autoimmune diseases: IMMUNO-CGRP study.

Headache·2026
Same author

Atogepant for migraine in real-world clinical practice: Insights from a large multicentre study in a treatment-resistant population (GEMA project).

Cephalalgia : an international journal of headache·2026

Related Experiment Video

Updated: Jun 8, 2026

An Investigation of the Effects of Sports-related Concussion in Youth Using Functional Magnetic Resonance Imaging and the Head Impact Telemetry System
07:02

An Investigation of the Effects of Sports-related Concussion in Youth Using Functional Magnetic Resonance Imaging and the Head Impact Telemetry System

Published on: January 12, 2011

15.9K

Structural brain changes in patients with persistent headache after COVID-19 resolution.

Álvaro Planchuelo-Gómez1,2, David García-Azorín3,4, Ángel L Guerrero5,6

  • 1Laboratorio de Procesado de Imagen (LPI), Universidad de Valladolid, 47011, Valladolid, Spain.

Journal of Neurology
|September 30, 2022
PubMed
Summary

Persistent headache after COVID-19 may involve subtle brain structural changes, differing from migraine. These findings suggest post-COVID headache could be an intermediate state between normal brain structure and migraine.

Keywords:
COVID-19Diffusion tensor imagingGray matterHeadacheMigraine

More Related Videos

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

18.3K
Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging
08:36

Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging

Published on: April 11, 2025

458

Related Experiment Videos

Last Updated: Jun 8, 2026

An Investigation of the Effects of Sports-related Concussion in Youth Using Functional Magnetic Resonance Imaging and the Head Impact Telemetry System
07:02

An Investigation of the Effects of Sports-related Concussion in Youth Using Functional Magnetic Resonance Imaging and the Head Impact Telemetry System

Published on: January 12, 2011

15.9K
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

18.3K
Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging
08:36

Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging

Published on: April 11, 2025

458

Area of Science:

  • Neuroimaging
  • Neurology
  • Infectious Disease Research

Background:

  • Headache is a common persistent symptom following COVID-19 recovery.
  • Understanding the neurological underpinnings of post-COVID headache is crucial.
  • Distinguishing post-COVID headache from primary headache disorders like migraine is important.

Purpose of the Study:

  • To investigate structural brain changes in patients with persistent headache post-COVID-19.
  • To compare these changes with those in healthy controls and patients with episodic and chronic migraine.
  • To explore whether post-COVID headache represents a distinct neurological state.

Main Methods:

  • Utilized T1-weighted and diffusion-weighted MRI scans from 167 subjects.
  • Assessed gray matter (cortical volume, thickness) and white matter (diffusion tensor imaging) parameters.
  • Compared data from COVID-19 recovered patients with persistent headache (COV), healthy controls, episodic migraine, and chronic migraine patients.

Main Results:

  • COV patients exhibited reduced cortical gray matter volume and thickness in specific brain regions compared to healthy controls.
  • COV patients showed altered white matter integrity (lower fractional anisotropy, higher radial diffusivity) in the corpus callosum and left hemisphere versus controls.
  • COV patients displayed distinct gray and white matter changes compared to migraine patients, suggesting a potentially intermediate neurological state.

Conclusions:

  • Persistent headache following COVID-19 is associated with specific, albeit subtle, structural brain alterations.
  • These changes differ from those observed in migraine, indicating post-COVID headache may be a unique condition.
  • Findings suggest post-COVID headache could represent an intermediate neurological state between normality and migraine.