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Emerging analytical techniques for pharmaceutical quality control: Where are we in 2022?
Amandine Dispas1, Pierre-Yves Sacré2, Eric Ziemons2
1University of Liege (ULiege), CIRM, Laboratory of Pharmaceutical Analytical Chemistry, Liège, Belgium; University of Liege (ULiege), CIRM, Laboratory for the Analysis of Medicines, Liège, Belgium.
Journal of Pharmaceutical and Biomedical Analysis
|September 30, 2022
Summary
Emerging spectroscopic and chromatographic techniques offer faster, cheaper, and greener pharmaceutical quality control (QC) solutions. This review explores advancements in vibrational spectroscopy and chromatography for improved drug analysis.
Area of Science:
- Analytical Chemistry
- Pharmaceutical Science
- Spectroscopy
- Chromatography
Background:
- Pharmaceutical quality control (QC) is essential for ensuring medicine safety and efficacy.
- Current QC methods, primarily liquid and gas chromatography, face challenges in speed, cost, and environmental impact.
- There is a growing need for innovative analytical techniques in pharmaceutical QC.
Purpose of the Study:
- To provide an overview of recent developments in emerging analytical technologies for pharmaceutical QC.
- To explore advancements in vibrational spectroscopy, supercritical fluid chromatography, and multi-dimensional chromatography.
- To analyze selected emerging techniques using SWOT analysis and review their applications in pharmaceutical QC.
Main Methods:
- Review of recent scientific literature on emerging analytical techniques.
- Application of SWOT (Strengths, Weaknesses, Opportunities, Threats) analysis to evaluate selected techniques.
- Discussion of published pharmaceutical quality control applications of these emerging technologies.
Main Results:
- Emerging techniques, including vibrational spectroscopy and advanced chromatography, show promise for pharmaceutical QC.
- These methods offer potential improvements in analysis time, cost-effectiveness, performance, and environmental sustainability.
- SWOT analysis provides a framework for understanding the advantages and limitations of these new technologies.
Conclusions:
- Vibrational spectroscopy and advanced chromatography represent significant advancements in pharmaceutical QC.
- These emerging techniques are poised to enhance the efficiency and reduce the environmental impact of drug analysis.
- Further research and application are encouraged to fully realize the potential of these innovative methods.
Keywords:
Multidimensional chromatographyNIR spectroscopyPharmaceuticalsQuality controlRaman spectroscopySupercritical fluid chromatographyVibrational spectroscopyMore Related Videos
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