Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

3.8K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.8K
Compact Bone01:27

Compact Bone

12.3K
Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
12.3K
The Bone Matrix01:18

The Bone Matrix

4.1K
Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
4.1K
What is the Skeletal System?01:02

What is the Skeletal System?

53.3K
Overview
53.3K
Blood and Nerve Supply to the Bones01:29

Blood and Nerve Supply to the Bones

11.6K
Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
11.6K
Spongy Bone01:09

Spongy Bone

4.9K
All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
4.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Understanding Charcot and Diabetic Bone Disease.

Clinics in podiatric medicine and surgery·2026
Same author

Erratum to 'Educational assessment of intrathoracic and extrathoracic surgical stabilization of rib fractures' [Injury volume 54 issue 1 (2023) pages 63-69].

Injury·2023
Same author

Effect of Participative Web-Based Educational Modules on HIV and Sexually Transmitted Infection Prevention Competency Among Medical Students: Single-Arm Interventional Study.

JMIR medical education·2023
Same author

Prospective single-center paradigm shift of surgical stabilization of rib fractures with decreased length of stay and operative time with an intrathoracic approach.

The journal of trauma and acute care surgery·2022
Same author

Beaming the Charcot Foot.

Clinics in podiatric medicine and surgery·2022
Same author

Outcomes of Artificial Intelligence Volumetric Assessment of Kidneys and Renal Tumors for Preoperative Assessment of Nephron-Sparing Interventions.

Journal of endourology·2021
Same journal

Lesser Toe Pathology: Challenges, Controversies, and Advances.

Clinics in podiatric medicine and surgery·2026
Same journal

Pathology of the Lesser Toes.

Clinics in podiatric medicine and surgery·2026
Same journal

Principles of Lesser Toe and Metatarsophalangeal Joint Reconstruction for Complex and Revision Surgery of the Forefoot.

Clinics in podiatric medicine and surgery·2026
Same journal

Biomechanical Problems Related to Lesser Toes Dysfunction and Amputation.

Clinics in podiatric medicine and surgery·2026
Same journal

Is It Necessary to Repair the Plantar Plate in the Management of Metatarsophalangeal Joint Instability?

Clinics in podiatric medicine and surgery·2026
Same journal

Lesser Metatarsophalangeal Joint Instability: Arthroscopic Treatment Alternatives.

Clinics in podiatric medicine and surgery·2026
See all related articles

Related Experiment Video

Updated: Aug 27, 2025

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
07:56

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

17.6K

Bone Metabolism in Charcot.

Lisa Grant-McDonald1, William Grant1

  • 1Tidewater Foot and Ankle, 760 Independence Boulevard, Virginia Beach, VA 23455, USA.

Clinics in Podiatric Medicine and Surgery
|September 30, 2022
PubMed
Summary
This summary is machine-generated.

Charcot neuro-osteoarthropathy causes intense bone turnover, leading to foot and ankle destruction. Understanding its metabolic pathogenesis is crucial for developing interventions for this devastating diabetic complication.

Keywords:
Charcot footDiabetic neuropathic osteoarthropathyPathogenesisReceptor activator of nuclear factor k-β ligand (RANKL)

More Related Videos

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
07:17

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation

Published on: April 14, 2016

84.5K
Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model
08:42

Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model

Published on: July 3, 2020

4.6K

Related Experiment Videos

Last Updated: Aug 27, 2025

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
07:56

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

17.6K
Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
07:17

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation

Published on: April 14, 2016

84.5K
Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model
08:42

Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model

Published on: July 3, 2020

4.6K

Area of Science:

  • Orthopedics
  • Metabolic Bone Disease
  • Diabetic Complications

Background:

  • Bone metabolism is typically stable in healthy adults but involves dynamic cellular processes.
  • Charcot neuro-osteoarthropathy is characterized by heightened bone turnover, causing skeletal degradation in the foot and ankle.
  • Despite recent interest, the metabolic pathogenesis of Charcot neuro-osteoarthropathy remains incompletely understood.

Purpose of the Study:

  • To review the current understanding of bone metabolism in Charcot neuro-osteoarthropathy.
  • To explore the metabolic pathways involved in this condition.
  • To identify potential therapeutic targets.

Main Methods:

  • Review of bone histology.
  • Analysis of physiologic bone metabolism.
  • Examination of biomarkers of bone metabolism.
  • Investigation of pathologic bone metabolism in diabetic patients with Charcot neuro-osteoarthropathy.

Main Results:

  • Charcot neuro-osteoarthropathy involves abnormal and accelerated bone turnover.
  • Specific cellular and molecular pathways contribute to the bone destruction seen in this condition.
  • Biomarkers may offer insights into disease activity and progression.

Conclusions:

  • Further research into the metabolic derangements of Charcot neuro-osteoarthropathy is essential.
  • A deeper understanding could lead to novel interventions to prevent or treat this debilitating disorder.
  • Targeting specific metabolic pathways may help preserve skeletal integrity in affected individuals.