Related Experiment Video
Updated: Jul 21, 2026

14:23
Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells
Published on: April 16, 2012
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A GMP Protocol for the Manufacture of Tregs for Clinical Application
Alice O'Neil1, Matthew Brook1, Seetha Abdul-Wahab1
1Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Methods in Molecular Biology (Clifton, N.J.)
|September 30, 2022
Abstract
None:
Infusion of regulatory T cells is a promising therapeutic strategy in organ transplantation to modulate the immune system, prevent rejection, minimize the need for pharmaceutical immunosuppression, and improve long-term transplant outcomes. Here we describe a GMP-compliant method we have used for the manufacture of ex vivo expanded autologous regulatory T cells for use in clinical trials.

