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Updated: Aug 27, 2025

Studying Diabetes Through the Eyes of a Fish: Microdissection, Visualization, and Analysis of the Adult tgfli:EGFP Zebrafish Retinal Vasculature
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Diabetic Embryopathies.

Saivaroon Gajagowni1, Pooja Nair1, Alka C Bapat2

  • 1University of Missouri School of Medicine, Columbia, MO.

Neoreviews
|September 30, 2022
PubMed
Summary
This summary is machine-generated.

Maternal diabetes can cause diabetic embryopathy, leading to birth defects like caudal regression syndrome. This review covers neonatal complications and long-term outcomes in infants born to diabetic mothers.

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Area of Science:

  • Endocrinology
  • Developmental Biology
  • Neonatology

Background:

  • Diabetic embryopathy encompasses congenital anomalies associated with maternal diabetes.
  • Established link between maternal diabetes and fetal, neonatal, and long-term infant complications.
  • Complications include organ maldevelopment, growth abnormalities, and neurodevelopmental issues.

Purpose of the Study:

  • To review neonatal morbidities in infants of diabetic mothers.
  • To focus on caudal regression syndrome (sacral agenesis) as a key complication.
  • To summarize long-term associations of these conditions.

Main Methods:

  • Literature review of existing research.
  • Focus on pathophysiology and management of diabetic embryopathy.
  • Synthesis of data on caudal regression syndrome and associated morbidities.

Main Results:

  • Diabetic embryopathy presents with diverse congenital anomalies.
  • Caudal regression syndrome is a significant, though less common, complication.
  • Infants face risks of structural malformations and developmental challenges.

Conclusions:

  • Maternal diabetes significantly impacts fetal development.
  • Early identification and management are crucial for affected infants.
  • Further research is needed on long-term outcomes and interventions.