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Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
Published on: May 30, 2025
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Long non-coding RNAs affecting cell metabolism in cancer
Massimiliano Agostini1, Mara Mancini2, Eleonora Candi3,4
1Department Experimental Medicine, University of Rome "Tor Vergata", TOR, Via Montpellier,1, 00133, Rome, Italy.
Biology Direct
|October 1, 2022
Summary
Cancer cells reprogram metabolism, altering glucose, lipid, and oxidative pathways. Long non-coding RNAs significantly influence these metabolic shifts in breast cancer progression.
Area of Science:
- Oncology
- Molecular Biology
- Metabolism
Background:
- Metabolic reprogramming is a key hallmark of cancer.
- Cancer cells exhibit altered glucose, lipid, and oxidative phosphorylation metabolism.
- Long non-coding RNAs (lncRNAs) are increasingly recognized for their role in cancer development.
Purpose of the Study:
- To provide an overview of metabolic reprogramming in breast cancer.
- To elucidate the role of long non-coding RNAs in driving cancer-specific metabolic alterations.
Main Methods:
- Literature review and synthesis of current research findings.
- Analysis of the interplay between lncRNAs and metabolic pathways in breast cancer.
Main Results:
- Breast cancer cells exhibit distinct metabolic alterations compared to normal cells.
- lncRNAs modulate key enzymes and pathways involved in cancer metabolism.
- Specific lncRNAs are implicated in promoting or suppressing breast cancer progression through metabolic control.
Conclusions:
- lncRNAs are critical regulators of metabolic reprogramming in breast cancer.
- Targeting lncRNAs offers potential therapeutic strategies for breast cancer by modulating cancer metabolism.
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