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Author Spotlight: Workflow for Integrating POCUS Data into EHR for Managing Heart Failure Patients
Published on: July 12, 2024
Managing Covid-19 in patients with heart failure: current status and future prospects
Hawani Sasmaya Prameswari1, Iwan Cahyo Santosa Putra1, Wilson Matthew Raffaello2
1Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.
Insights
This review addresses the lack of guidance on managing heart failure (HF) in COVID-19 patients. It aims to reduce morbidity and mortality by informing clinicians on optimal HF therapies during the pandemic.
Area of Science:
- Cardiology
- Infectious Diseases
- Pharmacology
Background:
- COVID-19 can worsen existing heart failure (HF) or cause new-onset HF due to hyperinflammation and increased metabolic demand.
- Current guidelines from WHO and NIH lack specific recommendations for HF drug choices in COVID-19 patients.
Approach:
- A comprehensive literature search was conducted across MEDLINE, Europe PMC, and ScienceDirect.
- 157 studies were included and rigorously evaluated by two independent investigators.
- The review synthesizes data on managing HF in the context of COVID-19.
Key Points:
- Lack of specific HF drug recommendations for COVID-19 patients.
- Potential for COVID-19 to precipitate or exacerbate heart failure.
- Need for evidence-based therapeutic strategies to mitigate adverse outcomes.
Conclusions:
- This review aims to fill the gap in comprehensive research on HF management during COVID-19.
- Providing clinicians with data to select beneficial therapies and avoid harmful combinations.
- Reducing morbidity and mortality in COVID-19 patients with heart failure.
Introduction:
COVID-19 may contribute to decompensation of previously stable chronic HF or cause a de-novo heart failure, which may come from the hyperinflammatory response and subsequent increase in metabolic demand.
Areas Covered:
Two independent investigators searched MEDLINE (via PubMed), Europe PMC, and ScienceDirect databases with the following search terms: COVID-19, heart failure, COVID-19 drugs, heart failure drugs, and device therapy. All of the included full-text articles were rigorously evaluated by both authors in case there was disagreement about whether research should be included or not. In total, 157 studies were included and underwent extensive reading by the authors.
Expert Opinion:
The World Health Organization (WHO) and the National Institute of Health (NIH) have published COVID-19 drug recommendations, although recommendations for HF-specific drug choices in COVID-19 are still lacking. We hope that this review can answer the void of comprehensive research data regarding the management options of HF in the COVID-19 condition so that clinicians can at least choose a more beneficial therapy or avoid combination therapies that have a high burden of side effects on HF; thus, morbidity and mortality in COVID-19 patients with HF may be reduced.
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