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Updated: Aug 5, 2026
07:38
Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension
Published on: January 20, 2023
Invasive Hemodynamic Predictors of Outcomes in Rheumatic Heart Disease With Echocardiographic RV-PA Uncoupling: A
Raissa Rafidhinar1, Jordan Budiono1, Melawati Hasan1
1Department of Cardiology and Vascular Medicine Faculty of Medicine, Universitas Padjadjaran, Hasan Sadikin General Hospital Bandung West Java Indonesia.
Pulmonary Circulation
|July 28, 2026
Summary
In rheumatic heart disease patients with right ventricular dysfunction, higher pulmonary vascular resistance predicts mortality, while lower RV function predicts adverse outcomes. These findings require further validation in larger studies.
Area of Science:
- Cardiology
- Pulmonology
- Clinical Hemodynamics
Background:
- Rheumatic heart disease (RHD) often involves pulmonary hypertension (PH) and right ventricular (RV) dysfunction.
- The prognostic value of invasive hemodynamic parameters in RHD patients with RV-pulmonary artery (PA) uncoupling is not well-established.
Purpose of the Study:
- To assess the association of invasive hemodynamic parameters from right heart catheterization (RHC) with mortality and adverse clinical outcomes in adults with RHD and RV-PA uncoupling.
Main Methods:
- A single-center retrospective cohort study included adults with RHD and echocardiographic RV-PA uncoupling undergoing RHC.
- Multivariable logistic regression analyzed associations between hemodynamic variables and outcomes.
Main Results:
- Higher pulmonary vascular resistance (PVR) was linked to all-cause mortality (OR 1.573).
- Lower RV fractional area change (FAC) (OR 0.885) and lower RV stroke work index (RVSWI) (OR 0.819) were associated with a composite adverse outcome.
Conclusions:
- In RHD patients with RV-PA uncoupling, elevated PVR predicts mortality.
- Reduced RV FAC and RVSWI are associated with adverse clinical outcomes, suggesting their prognostic importance.
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