The Emerging Role of Noncoding RNA Regulation of the Ferroptosis in Cardiovascular Diseases

Area of Science:

• Biomedical Science
• Molecular Biology
• Cardiovascular Research

Background:

• Cardiovascular disease (CVD) poses a major global health challenge.
• Genetic factors, particularly noncoding RNAs, are increasingly recognized for their role in CVD progression.
• Ferroptosis, a distinct form of regulated cell death (RCD), is implicated in various cardiovascular conditions.

Purpose of the Study:

• To review current research on noncoding RNA's regulation of ferroptosis.
• To explore the involvement of ferroptosis in the pathogenesis of cardiovascular diseases.
• To discuss potential therapeutic implications of targeting noncoding RNA-mediated ferroptosis in CVD.

Main Methods:

• Literature review of recent scientific findings.
• Analysis of studies investigating noncoding RNA function in gene regulation.
• Examination of research on ferroptosis mechanisms and its role in CVD models.

Main Results:

• Noncoding RNAs are crucial for gene regulation and development.
• Ferroptosis, characterized by lipid peroxidation and redox imbalance, differs significantly from other RCD types.
• Evidence links ferroptosis to cardiac ischemia/reperfusion injury, heart failure, and aortic dissection.

Conclusions:

• Noncoding RNA regulation of ferroptosis is a key factor in CVD development.
• Targeting this pathway presents promising avenues for novel CVD treatments.
• Further research is needed to fully elucidate the noncoding RNA-ferroptosis-CVD axis.