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Hypopigmented penile fixed drug eruption
Perpetua U Ibekwe1, Hafees O Ajibola2, Zainabb Babba3
1Department of Medicine, College of Health Sciences University of Abuja Abuja Nigeria.
Clinical Case Reports
|October 3, 2022
Summary
Fixed drug eruptions (FDE) can present with hypopigmentation, unlike typical presentations. This case highlights a prolonged drug provocation test (DPT) refractory period and recurrent meatal stenosis in penile FDE.
Area of Science:
- Dermatology
- Urology
Background:
- Fixed drug eruptions (FDE) are typically characterized by residual hyperpigmentation or non-pigmenting lesions after resolution.
- Histopathological examination lacks distinctive features for FDE diagnosis.
Observation:
- A case of penile fixed drug eruption (FDE) is presented.
- The patient exhibited residual hypopigmentation, a rare presentation of FDE.
- A prolonged refractory period to drug provocation tests (DPT) was noted.
Findings:
- The patient experienced recurrent meatal stenosis in conjunction with penile FDE.
- Drug provocation tests (DPT) were confirmatory for FDE but required an extended period due to refractoriness.
- Penile FDE can manifest with hypopigmentation and be associated with urological complications like meatal stenosis.
Implications:
- This case expands the clinical spectrum of FDE presentations, including hypopigmentation.
- It underscores the potential for prolonged refractory periods in DPT, necessitating careful clinical evaluation.
- The association with recurrent meatal stenosis suggests a potential link between FDE and specific urological sequelae, warranting further investigation.
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