Capillary Electromigration Techniques Coupled to Mass Spectrometry: Applications to Food Analysis

Area of Science:

• Analytical Chemistry
• Food Science
• Biochemistry

Background:

• Food analysis is crucial for safety, quality, regulatory compliance, and research.
• Capillary electrophoresis-mass spectrometry (CE-MS) is a versatile hyphenated technique for analyzing diverse food analytes.
• CE-MS offers high efficiency, resolution, low reagent costs, and a fast, green analytical approach.

Purpose of the Study:

• To provide a comprehensive review of CE-MS applications in food analysis.
• To evaluate literature published between July 2010 and October 2020.
• To outline recent advances and future trends in foodomics using CE-MS.

Main Methods:

• Review of open literature on CE-MS applications in food analysis.
• Compilation of principles for various CE-MS modes and CE-inductively coupled plasma mass spectrometry.
• Summary of ionization interfaces and sample preparation techniques for diverse food matrices.

Main Results:

• CE-MS has been extensively applied to various food types, from small ions to macromolecules.
• The review details different CE-MS configurations and their suitability for specific food analyses.
• Key advances in sample preparation and interface technologies have enhanced CE-MS capabilities.

Conclusions:

• CE-MS is a valuable and evolving technique for detailed food analysis.
• Its efficiency, resolution, and green characteristics make it ideal for food safety, quality, and research.
• Future trends indicate expanded use in foodomics and complex food system investigations.