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Updated: Aug 26, 2025

Intrastriatal Injection of Autologous Blood or Clostridial Collagenase as Murine Models of Intracerebral Hemorrhage
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Relationship between Cholesterol Level and Spontaneous Intracerebral Hemorrhage: A Case-Control Study in Bangladesh

K A Talha1, F Selina, M I Patwary

  • 1Dr Khandaker Abu Talha, Associate Professor of Neurosurgery, Sylhet Women's Medical College, Sylhet, Bangladesh;

Mymensingh Medical Journal : MMJ
|October 3, 2022
PubMed

Insights

Lower cholesterol levels, including total cholesterol, triglycerides, and LDL, were associated with a reduced risk of intracerebral hemorrhage (ICH). However, higher HDL cholesterol showed a significant association with increased ICH risk.

Area of Science:

  • Neurology
  • Cardiovascular Science
  • Genetics

Background:

  • Spontaneous intracerebral hemorrhage (ICH) is a major cause of death and disability.
  • Genetic factors contribute to ICH, but non-genetic factors like cholesterol levels are also significant risk factors.
  • Understanding the role of lipid profiles in ICH is crucial for risk assessment and prevention.

Purpose of the Study:

  • To investigate the association between intracerebral hemorrhage (ICH) and cholesterol levels.
  • To determine the risk associated with total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) in ICH.
  • To explore the impact of lipid profiles on the incidence of spontaneous ICH.

Main Methods:

  • A retrospective case-control study was conducted.
  • The study included 60 patients with ICH (cases) and 60 age- and sex-matched controls.
  • Lipid profiles (TC, TG, HDL, LDL) were analyzed and compared between the groups.

Main Results:

  • Mean levels of TC, TG, and LDL were significantly lower in the ICH group compared to controls.
  • Mean HDL levels were significantly higher in the ICH group than in the control group.
  • Lower TC, TG, and LDL levels were associated with a reduced risk of ICH, while higher HDL was linked to an increased risk.

Conclusions:

  • Cholesterol levels, particularly TC, TG, and LDL, show a significant inverse association with intracerebral hemorrhage.
  • Elevated HDL cholesterol levels may be associated with an increased risk of ICH.
  • Further research is warranted to elucidate the complex relationship between lipid profiles and ICH pathogenesis.

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