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Time matters - in vitro cellular disposition kinetics help rationalizing cellular potency disconnects.

Birk Poller1, Sophie Werner1, Norbert Domange1

  • 1Pharmacokinetic Sciences, Novartis Institutes for Biomedical Research, Basel, Switzerland.

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
|October 3, 2022
PubMed
Summary

A new assay measures cellular drug uptake, revealing how drug potency changes between biochemical and cellular tests. This helps identify drugs with potency disconnects early in discovery.

Keywords:
Permeabilitycellular binding (Kp)cellular uptake (PSinf)free drug hypothesispotency disconnectprotein degraders

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