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Published on: September 25, 2019
Association of Lesion Location and Depressive Symptoms Poststroke
Julian Klingbeil1, Max-Lennart Brandt1, Max Wawrzyniak1
1Department of Neurology (J.K., M.-L.B., M.W., A.S., H.R.S., P.B., D.S.), University of Leipzig Medical Center, Germany.
Background:
Depressive symptoms are a common stroke sequela, yet their neurobiological substrates are still unclear. We sought to determine if they are associated with specific lesion locations.
Methods:
In a prospective observational study, 270 patients with stroke were tested twice with the Hospital Anxiety and Depression Scale around day 6 and again 6 months poststroke and voxel-based lesion behavior mapping was performed.
Results:
Frequency of depressive symptoms (depression subscale of the Hospital Anxiety and Depression Scale >7) after 6 months was 19.6 %. Higher Hospital Anxiety and Depression Scale scores for depression around day 6 were the only variable associated with depressive symptoms after 6 months in a multiple logistic regression. Lesions in the right putamen were significantly associated with depressive symptoms after 6 months in the voxel-based lesion behavior mapping.
Conclusions:
Lesions in the right basal ganglia might increase the risk of depressive symptoms 6 months poststroke.
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