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Updated: Jun 21, 2026

Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG

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Cortical structural changes after subcortical stroke: Patterns and correlates.

Jingchun Liu¹, Caihong Wang², Wen Qin¹

¹Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, China.

Human Brain Mapping

|October 3, 2022

Summary

This summary is machine-generated.

Subcortical stroke causes brain structure changes that differ based on motor recovery. Complete recovery is linked to brain region expansion, while partial recovery shows shrinkage, highlighting distinct recovery patterns.

Keywords:

brain structure corticospinal tract magnetic resonance imaging stroke voxel-based lesion-symptom mapping

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Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke

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Published on: July 14, 2023

Area of Science:

Neuroscience
Neurology
Radiology

Background:

Subcortical ischemic stroke can cause lasting cerebral cortex structural changes.
The progression of these cortical changes and their relationship with motor recovery, lesion site, and corticospinal tract (CST) integrity remain unclear.

Purpose of the Study:

To investigate the evolution of cortical structural changes after subcortical stroke.
To explore the association between these changes, motor recovery, lesion location, and corticospinal tract (CST) fiber integrity.

Main Methods:

Compared cortical structural changes in 181 chronic subcortical stroke patients versus 113 healthy controls.
Utilized voxel-based correlation and association studies to link lesion location and CST damage to cortical changes.
Employed linear mixed-effects models to analyze longitudinal structural changes in 81 stroke patients.

Main Results:

Patients with partial recovery showed reduced cortical thickness, surface area, and gray matter volume in sensorimotor areas compared to those with complete recovery.
Complete recovery was associated with increased cortical measures in frontal, temporal, and occipital regions.
Lesion location and early CST impairment correlated with specific chronic-stage cortical structural changes, with differing patterns between partial and complete recovery groups.

Conclusions:

Cortical structural changes after subcortical stroke are complex and evolve dynamically.
Recovery patterns (partial vs. complete) exhibit distinct longitudinal cortical structural changes.
These changes are significantly associated with the stroke's initial lesion location and the specific corticospinal tract (CST) fibers affected.