Application of lignin and lignin-based composites in different tissue engineering fields

Area of Science:

• Biomaterials Science
• Polymer Chemistry
• Regenerative Medicine

Background:

• Lignin, a complex phenolic polymer from plant biomass, possesses abundant functional groups.
• These functional groups impart antioxidant, antimicrobial, and immune-modulating properties to lignin.
• Lignin's biological activities make it a promising candidate for biomedical applications, particularly in tissue engineering.

Approach:

• This review systematically summarizes recent advancements in lignin-based composites for tissue engineering.
• It highlights the biological functions of lignin and its derivatives.
• The focus is on applications in bone regeneration, organ regeneration, and wound dressing.

Key Points:

• Lignin's inherent bioactive properties are leveraged in developing advanced biomaterials.
• Lignin-based composites demonstrate efficacy in promoting tissue repair and regeneration.
• Specific applications include enhancing bone defect repair, supporting organ regeneration, and improving wound healing outcomes.

Conclusions:

• Lignin and its composites offer significant potential for diverse tissue engineering applications.
• Further research can optimize lignin-based materials for enhanced clinical translation.
• This review serves as a guide for future development in lignin-based biomedical technologies.