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Hypertrophic cardiomyopathy in a patient with secondary hypoparathyroidism: A case report

Juan Felipe Betancur1, Christian Adams-Sánchez2, Lina Restrepo-Giraldo3

  • 1Leader Internal Medicine Research Group, Ayudas Diagnosticas SURA Biociencias I+D, Internal Medicine Department, Clínica Medellín - Grupo Quirónsalud, CES University, Medellín, Colombia.

Radiology Case Reports
|October 4, 2022
PubMed

Insights

Chronic hypoparathyroidism can affect the heart, typically causing dilated cardiomyopathy. This case study presents a rare instance of hypertrophic cardiomyopathy in a patient with chronic hypoparathyroidism and hypocalcemia.

Area of Science:

  • Cardiology
  • Endocrinology
  • Molecular Biology

Background:

  • Parathyroid hormone (PTH) influences cardiovascular cells, but the cardiac effects of chronic hypoparathyroidism remain incompletely understood.
  • Low PTH states are linked to various acute and chronic cardiac manifestations.
  • Hypocalcemic cardiomyopathy can present acutely as transient dilated cardiomyopathy or chronically, potentially leading to heart failure.

Observation:

  • This study details a 73-year-old woman with chronic hypoparathyroidism and hypocalcemia.
  • The patient developed hypertrophic cardiomyopathy.
  • This presentation is atypical, as chronic hypoparathyroidism-associated cardiomyopathy usually manifests as dilated cardiomyopathy.

Findings:

  • Chronic hypoparathyroidism can lead to diverse cardiac pathologies beyond the typical dilated form.
  • Hypertrophic cardiomyopathy is an unusual manifestation of chronic hypoparathyroidism and hypocalcemia.
  • This case highlights the varied cardiac remodeling possible in low PTH states.

Implications:

  • Clinicians should consider hypertrophic cardiomyopathy in patients with chronic hypoparathyroidism presenting with cardiac abnormalities.
  • Further research is needed to elucidate the mechanisms underlying different forms of hypoparathyroidism-associated cardiomyopathy.
  • Understanding these associations can improve diagnosis and management of cardiac complications in hypoparathyroid patients.

Keywords:
Basal ganglia calcificationBilateral striopallidadodentate calcinosisHypoparathyroid cardiomyopathyHypoparathyroidism

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