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Updated: Aug 26, 2025

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Synthesis and characterization of a bimetallic americium(III) pyrithionate coordination complex
Zachary K Huffman1, Joseph M Sperling1, Cory J Windorff1,2
1Department of Chemistry and Biochemistry, Florida State University, 95 Chieftan Way, Tallahassee, Florida, 32306, USA. cristian.andree@gmail.com.
Abstract:
The aqueous reaction of sodium pyrithione, (Na)mpo, with 243AmCl3·nH2O yields a dimerized complex, [243Am(mpo)2(μ-O-mpo)(H2O)]2·3H2O. This compound is compared with isostructural lanthanide pyrithionates, where dimerization across the 4f-block is observed to be dependent upon the size of the cation. Unlike in most reported Am(III) UV-visible absorption spectra, [243Am(mpo)2(μ-O-mpo)(H2O)]2·3H2O shows significant splitting in the fingerprint excitations. This is attributed to a unique ligand-field environment, where the Am-mpo bonds possess different bonding compared to the Nd(III) analog because of increasing covalent interactions.
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