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Metastasis02:30

Metastasis

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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Related Experiment Video

Updated: Aug 26, 2025

Author Spotlight: Decoding Metastasis-to-Metastasis Seeding Using a New In Vivo Technique for Tracking Breast Cancer Spread
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Author Spotlight: Decoding Metastasis-to-Metastasis Seeding Using a New In Vivo Technique for Tracking Breast Cancer Spread

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Charting metastasis.

Amy E Baek1

  • 1Science Signaling, AAAS, Washington, DC 20005, USA.

Science Signaling
|October 4, 2022
PubMed
Summary

A specific group of melanoma cells can sense their surroundings and spread from tumors. This understanding is key to developing new strategies against melanoma metastasis.

Area of Science:

  • Oncology
  • Cell Biology
  • Cancer Research

Background:

  • Melanoma is an aggressive skin cancer with a high potential for metastasis.
  • The tumor microenvironment plays a critical role in cancer progression and dissemination.

Purpose of the Study:

  • To investigate the behavior of melanoma cells in response to microenvironmental signals.
  • To identify the subpopulation of melanoma cells responsible for dissemination.

Main Methods:

  • Utilized advanced imaging techniques to observe melanoma cell behavior in situ.
  • Employed single-cell analysis to characterize subpopulations based on their response to microenvironmental cues.

Main Results:

  • Identified a distinct subpopulation of melanoma cells that actively respond to specific microenvironmental cues.

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  • Demonstrated that this subpopulation is responsible for the dissemination of melanoma from primary lesions.

    • Conclusions:

    • Microenvironmental cues are critical drivers of melanoma cell dissemination.
    • Targeting the interaction between melanoma cells and their microenvironment may offer a novel therapeutic strategy to prevent metastasis.