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Characteristics of gastroesophageal reflux disease in children with interstitial lung disease

Marcin Dziekiewicz1, Honorata Marczak2, Marcin Banasiuk1

  • 1Department of Pediatric Gastroenterology and Nutrition, Medical University of Warsaw, Warsaw, Poland.

Pediatric Pulmonology
|October 5, 2022
PubMed

Insights

Gastroesophageal reflux disease (GERD) is common in children with interstitial lung disease (chILD). However, this study found no link between proximal reflux and chILD, questioning the microaspiration theory.

Area of Science:

  • Pediatric Pulmonology
  • Gastroenterology
  • Rare Diseases

Background:

  • Childhood interstitial lung disease (chILD) is a rare respiratory disorder.
  • Gastroesophageal reflux disease (GERD) is a potential contributing factor to chILD pathogenesis via microaspiration.
  • The relationship between GERD and chILD requires further investigation.

Purpose of the Study:

  • To determine the prevalence and characteristics of GERD in children diagnosed with chILD.
  • To specifically assess the frequency and impact of proximal gastroesophageal reflux (GER) episodes in this population.
  • To evaluate the association between GERD and microaspiration in chILD.

Main Methods:

  • A prospective cross-sectional study design was employed.
  • Sixty-two children with chILD underwent 24-hour multichannel intraluminal pH-impedance monitoring.
  • Gastroesophageal reflux episodes were categorized and compared between GERD-positive and GERD-negative subgroups.

Main Results:

  • GERD was diagnosed in 32.3% of the pediatric patients with chILD.
  • GERD-positive children exhibited significantly higher esophageal acid exposure, total GER episodes, and acid GER episodes.
  • No significant difference was observed in the number of proximal GER episodes between GERD-positive and GERD-negative children.

Conclusions:

  • The study indicates a high frequency of GERD in children with chILD.
  • The findings do not support an association between proximal GER and GERD diagnosis in chILD.
  • Further research using refined aspiration assessment methods is necessary to validate or refute the microaspiration theory linking GERD and chILD.
Abstract

Keywords:
childhood interstitial lung diseasegastroesophageal reflux diseasepH-impedancepersistent infantile tachypnea

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