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Updated: Aug 26, 2025

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Aptamer-Based Target Detection Facilitated by a 3-Stage G-Quadruplex Isothermal Exponential Amplification Reaction
Published on: October 6, 2022
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Ligand-based drug repurposing strategy identified SARS-CoV-2 RNA G-quadruplex binders
Federica Moraca1,2, Simona Marzano1, Francesco D'Amico3
1Department of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy. bruno.pagano@unina.it.
Abstract:
The single-stranded RNA genome of SARS-CoV-2 contains some G-quadruplex-forming G-rich elements which are putative drug targets. Here, we performed a ligand-based pharmacophore virtual screening of FDA approved drugs to find candidates targeting such RNA structures. Further in silico and in vitro assays identified three drugs as emerging SARS-CoV-2 RNA G-quadruplex binders.

