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Clinical Registries in Dry Eye Disease: A Systematic Review.
Pauline Khoo1, Laura E Downie2, Fiona Stapleton3
1The University of Sydney, Save Sight Institute, Discipline of Ophthalmology, Sydney Medical School, Sydney, New South Wales, Australia.
Cornea
|October 5, 2022
Summary
This systematic review found few clinical registries adequately capture dry eye disease (DED) data, particularly for evaporative DED. Developing a comprehensive DED registry is crucial for understanding this prevalent condition.
Area of Science:
- Ophthalmology
- Clinical Informatics
- Systematic Reviews
Background:
- Dry eye disease (DED) is a prevalent condition with various subtypes, including aqueous deficient and evaporative.
- Existing clinical registries in ophthalmology often lack specific data collection for DED parameters.
- Understanding DED requires robust data from well-designed patient registries.
Approach:
- A systematic literature review was conducted to identify ophthalmology clinical registries.
- Searches focused on registries reporting dry eye parameters.
- Two independent reviewers assessed titles, abstracts, and full texts for eligibility.
Key Points:
- 129 ophthalmology registries were identified; common conditions included blindness, glaucoma, and corneal transplantation.
- Only 8 registries reported on dry eye parameters, with one specifically for DED patients.
- Most identified registries focused on aqueous deficient dry eye, not the more common evaporative type.
Conclusions:
- Current clinical registries have limitations in capturing comprehensive dry eye disease data.
- There is a need for well-designed, international registries to address DED knowledge gaps.
- Improved data collection in DED registries can advance understanding and management of this widespread disease.
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