Optimized parameters for effective SARS-CoV-2 inactivation using UVC-LED at 275 nm

Area of Science:

• Medical Devices
• Infectious Disease Control
• Photochemistry

Background:

• The COVID-19 pandemic necessitates rapid development of countermeasures against SARS-CoV-2.
• Viral mutations pose an ongoing threat, requiring innovative solutions beyond current treatments.
• Medical devices with virus-eradication capabilities are crucial for preventing transmission.

Purpose of the Study:

• To develop and assess a portable UVC-LED medical device for SARS-CoV-2 disinfection.
• To determine the optimal parameters for UVC-LED inactivation of SARS-CoV-2.
• To evaluate the potential of UVC-LED technology in enhancing medical environment safety.

Main Methods:

• Development of a portable, rechargeable UVC-LED disinfection device.
• Investigation of the antiviral efficacy of 275 nm UVC-LED against SARS-CoV-2.
• Systematic analysis of irradiation distance and exposure time effects on viral inactivation.

Main Results:

• The device achieved 99.9% SARS-CoV-2 disinfection in less than 10 seconds, with a 6-hour operational duration.
• Optimal inactivation (≥99.99% reduction) was achieved with irradiation distances of 10-20 cm, exposure times <10 seconds, and UV doses >10 mJ/cm².
• UVC-LED systems demonstrated advantages including rapid intensity stabilization and temperature insensitivity.

Conclusions:

• Short-term UVC-LED irradiation is highly effective for SARS-CoV-2 inactivation.
• The developed portable device shows promise for containing SARS-CoV-2 infection.
• Findings may inform guidelines for creating safer medical environments using UVC-LED technology.