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Updated: Aug 26, 2025

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin
Published on: May 6, 2018
The Vicious Cycle of Hypothyroidism and Severe Proteinuria: A Case Report
Shuojohn Li1, Mahmoud Alsaiqali2, Meenakshi Narayanaswamy2
1Internal Medicine, State University of New York Downstate Health Sciences University, Brooklyn, USA.
Abstract:
Severe proteinuria and nephrotic syndrome are well documented causes or exacerbating factor of hypothyroidism. Less commonly known is that hypothyroidism, one of the most commonly encountered endocrinopathies, also has a profound effect on renal function and may lead to proteinuria. Here we report a case of female patient with hypothyroidism who presented with new onset severe proteinuria. Based on clinical data, we suspect the patient may have entered a vicious cycle of hypothyroidism and severe proteinuria where the two conditions worsen each other. Through literature review, we provide summaries of evidence supporting this bidirectional relationship between hypothyroidism and proteinuria, and emphasize on the importance of recognizing such association in clinical practice.
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