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From Constructs to Crystals – Towards Structure Determination of β-barrel Outer Membrane Proteins
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Bacterial Outer Membrane Polysaccharide Export (OPX) Proteins Occupy Three Structural Classes with Selective β-Barrel

Fares Saïdi1,2, Utkarsha Mahanta3, Adyasha Panda3

  • 1Institut National de la Recherche Scientifique (INRS), Centre Armand-Frappier Santé Biotechnologie, Université du Québec, Institut Pasteur International Network, Laval, Quebec, Canada.

Microbiology Spectrum
|October 6, 2022
PubMed
Summary

Most bacterial outer membrane polysaccharide export (OPX) proteins lack the ability to span the membrane. In Myxococcus xanthus, secretion relies on novel outer membrane beta-barrel porins, termed Wzp, facilitating polysaccharide transport and offering new antimicrobial targets.

Keywords:
ABC transporter-dependent pathwayDUF6029Wzx/Wzy-dependent pathwaybiofilmscapsule polysaccharidegenomicsouter membraneouter membrane proteinsperiplasm thicknessporinssecretion systemssynthase-dependent pathway

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