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Technical note: A method for generating lesion-specific nonuniform rotational margins for targets remote from

Christian Dial¹, Vikren Sarkar¹, Geoff Nelson¹

¹Department of Radiation Oncology, University of Utah, 1950 Circle of Hope Dr., Salt Lake City, Utah, USA.

Medical Physics

|October 6, 2022

Summary

This study introduces a new method for creating precise rotational margins in radiotherapy, reducing treated volumes for tumors far from the isocenter. The technique accounts for target shape and rotational uncertainty, improving treatment accuracy.

Keywords:

margins multiple metastases radiosurgery rotational uncertainties stereotactic

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Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

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Area of Science:

Medical Physics
Radiation Oncology
Radiotherapy Planning

Background:

Single isocenter multiple metastasis radiotherapy (SIMRT) presents challenges for targets remote from the isocenter.
Accurate rotational margin generation is crucial for effective dose delivery and minimizing off-target exposure.

Purpose of the Study:

To develop and validate a novel method for generating nonuniform, lesion-specific rotational margins.
To address the complexities of rotational uncertainty for targets distant from the isocenter in SIMRT.

Main Methods:

A series of 3D rotations were used to create a rotational envelope encompassing potential motion.
Simulations involved artificial spherical targets at varying distances from isocenter with specified rotational uncertainties.
Hausdorff distances and volume differences were calculated to assess margin accuracy and potential volume reduction compared to uniform expansions.

Main Results:

Rotational envelopes were generated efficiently, with median computation time of 60 seconds.
Maximum Hausdorff distances increased with greater rotational uncertainty and distance from isocenter.
Significant reductions in treated target volumes were observed, averaging 45% compared to uniform expansions.

Conclusions:

A novel method for generating lesion-specific rotational margins using 3D rotation sampling was successfully presented.
The method accurately accounts for target geometry, distance from isocenter, and rotational uncertainty.
This approach offers a potential advantage by reducing treated volumes compared to traditional uniform expansions.