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Updated: Aug 26, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Silver-Catalyzed 1,3-Aza-Benzyl Migration of Allyl Alcohol
Chuan-Ming Hong1, Si-Qi Xiong1, Xue Zhang1
1School of Chemistry and Chemical Engineering, Southwest University, Chongqing400715, China.
Abstract:
Carbon migration of alkenyl alcohols has been recognized as an increasingly viable methodology in organic synthesis. Herein, we disclose a silver-catalyzed 1,3-aza-benzyl migration of allyl alcohols by utilizing chelation-assisted selective cleavage of an unstrained C(sp3)-C(sp3) bond. This approach provides an available, efficient, high atom-economic, and environmentally benign procedure, leading to alkylation products with broad substrate scopes and excellent yields. The migration proceeds via a one-pot, two-step process involving a free-state alkyl metal species.
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