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Related Experiment Video

Updated: Aug 26, 2025

Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management
09:17

Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management

Published on: February 28, 2025

411

3D bioprinted extracellular vesicles for tissue engineering-a perspective.

Pingping Han1,2, Sašo Ivanovski1,2

  • 1The University of Queensland, Faculty of Health and Behavioural Sciences, School of Dentistry, Center for Oral-facial Regeneration, Rehabilitation and Reconstruction (COR3), School of Dentistry, Brisbane, QLD 4006, Australia.

Biofabrication
|October 6, 2022
PubMed
Summary
This summary is machine-generated.

Three-dimensional (3D) bioprinted extracellular vesicles (EVs) offer a promising cell-free approach for tissue engineering. This technology enhances targeted delivery and overcomes challenges associated with live cells in regenerative medicine.

Keywords:
3D bioprinted extracellular vesiclespersonalized medicinetissue engineering

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Nanotechnology

Background:

  • Extracellular vesicles (EVs) are natural nanoparticles used as cell-free nanotherapeutics.
  • Conventional 3D bioprinting uses bioinks with live cells for tissue regeneration.
  • EVs offer advantages over live cells, including targeted delivery and improved cost-effectiveness.

Purpose of the Study:

  • To explore the applications of 3D bioprinted EVs in tissue engineering.
  • To examine technical challenges and future trends in 3D bioprinted EV biofabrication.
  • To propose a personalized bioprinted EVs concept for clinical translation.

Main Methods:

  • Literature review of 3D bioprinted EVs applications.
  • Analysis of existing research in tissue engineering.
  • Examination of technical challenges and future directions.

Main Results:

  • 3D bioprinted EVs show promise in angiogenesis, osteogenesis, chondrogenesis, myogenesis, and carcinoprevention.
  • Key challenges in biofabrication and tissue engineering were identified.
  • A workflow for clinical translation of bioprinted EVs was proposed.

Conclusions:

  • 3D bioprinted EVs represent a significant advancement in regenerative medicine.
  • Addressing technical challenges is crucial for clinical translation.
  • Personalized bioprinted EVs offer a future direction for tailored therapies.