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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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Evolving therapeutic proteins to precisely kill cancer cells.

Rahela Zaman1, Rowshan Ara Islam2, Ezharul Hoque Chowdhury1

  • 1Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, 47500 Subang Jaya, Selangor, Malaysia.

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Traditional cancer therapies like chemotherapy cause severe side effects and resistance. Peptide and protein therapeutics offer targeted, tissue-specific cancer treatment with reduced toxicity.

Keywords:
Antibody therapeuticsCancerProtein &amp; peptide therapeuticTargeted therapeutic

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Area of Science:

  • Oncology
  • Biochemistry
  • Pharmacology

Background:

  • Current cancer treatments, including chemotherapy and radiation, face limitations such as severe side effects and the development of drug resistance.
  • Chemotherapy targets rapidly dividing cells, leading to damage of healthy tissues and failure to address tumor heterogeneity.
  • Tumorigenesis involves specific protein activity alterations, presenting opportunities for targeted therapeutic interventions.

Purpose of the Study:

  • To review current and emerging peptide and protein-based precision therapeutics in oncology.
  • To highlight technological advancements in the development of protein and peptide-based cancer treatments.
  • To discuss the shift from cytotoxic small molecule therapies to targeted cytostatic strategies.

Main Methods:

  • Literature review of peer-reviewed articles and clinical trial data.
  • Analysis of scientific publications on peptide and protein therapeutics in cancer.
  • Examination of technological innovations in biopharmaceutical development for oncology.

Main Results:

  • Peptide and protein therapeutics offer a tissue-specific and cytostatic approach to cancer treatment, minimizing drug toxicity.
  • Targeting specific somatic alterations in cancer cells enables precision medicine strategies.
  • Advancements in biopharmaceutical technology are facilitating the development of novel protein and peptide-based drugs.

Conclusions:

  • Peptide and protein-based therapeutics represent a promising paradigm shift in cancer treatment, moving towards targeted and less toxic strategies.
  • Precision oncology increasingly relies on identifying and targeting specific molecular signatures of cancer.
  • Continued research and technological innovation are crucial for advancing peptide and protein-based cancer therapies.