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Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology
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Published on: March 22, 2012

Secondary amyloidosis in association with Aspergillus lung disease

J H Winter, R Milroy, R D Stevenson

    British Journal of Diseases of the Chest
    |October 1, 1986
    PubMed

    Insights

    Chronic Aspergillus allergy may lead to amyloidosis in patients with bronchiectasis. This suggests some tuberculosis-related amyloidosis cases might stem from Aspergillus allergy.

    Area of Science:

    • Pulmonary Medicine
    • Immunology
    • Pathology

    Background:

    • Amyloidosis is a rare complication of chronic inflammatory lung diseases.
    • Bronchiectasis, a condition involving permanent lung damage, can predispose individuals to chronic infections and inflammation.

    Observation:

    • This study describes three patients with amyloidosis secondary to bronchiectasis.
    • Two patients had bronchiectasis linked to allergic bronchopulmonary aspergillosis.
    • The third patient had post-tuberculous bronchiectasis with co-existing asthma and Aspergillus allergy.

    Findings:

    • Chronic Aspergillus allergy is proposed as a potential cause of amyloidosis.
    • This challenges the traditional attribution of some amyloidosis cases solely to tuberculosis.

    Implications:

    • Re-evaluating the etiology of amyloidosis in patients with a history of tuberculosis is recommended.
    • Recognizing Aspergillus allergy as a potential driver of amyloidosis may improve diagnosis and treatment strategies for affected individuals.

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