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Acoustocerebrography in septic patients: A randomized and controlled pilot study.

Martin Sauer1,2,3, Anika Sievert1, Miroslaw Wrobel2

  • 1Department of Anesthesiology and Intensive Care Medicine, University Hospital Rostock, Rostock, Germany.

Frontiers in Medical Technology
|October 7, 2022
PubMed
Summary

Acoustocerebrography (ACG) shows promise in diagnosing sepsis-associated encephalopathy (SAE). This ultrasound method achieved 83.4% accuracy in detecting acute brain injury in septic patients, aiding diagnosis.

Keywords:
critical illnessdeliriumencephalopathymolecular acousticsevere sepsis

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Area of Science:

  • Neurology
  • Medical Imaging
  • Critical Care Medicine

Background:

  • Sepsis-associated encephalopathy (SAE) is a frequent complication of severe sepsis/septic shock, increasing mortality and hospital stay.
  • Current SAE diagnosis relies on exclusion criteria, lacking specific biomarkers or imaging techniques.
  • Acute brain injury in sepsis requires reliable diagnostic tools for timely intervention.

Purpose of the Study:

  • To evaluate the efficacy of acoustocerebrography (ACG) in detecting acute brain injury in septic patients.
  • To assess the diagnostic accuracy of ACG for sepsis-associated encephalopathy (SAE).
  • To explore molecular acoustics as a potential diagnostic method for SAE.

Main Methods:

  • Prospective, controlled clinical study involving 20 patients (septic shock group vs. control group).
  • Utilized acoustocerebrography (ACG), a multifrequency transcranial ultrasound, to measure brain tissue changes.
  • Collected blood parameters, sepsis-related organ failure assessment scores, and delirium scores (CAM-ICU, ICDSC).

Main Results:

  • ACG analysis demonstrated an accuracy of 83.4% in predicting acute brain injury.
  • The method showed a specificity of 89.0% and a sensitivity of 75.1% for SAE detection.
  • Septic shock patients exhibited positive delirium scores (CAM-ICU, ICDSC), unlike the control group.

Conclusions:

  • Acoustocerebrography (ACG) shows potential as a non-invasive tool for monitoring and diagnosing acute brain injury in septic patients.
  • Further clinical studies are warranted to validate these findings and compare ACG with established diagnostic methods like EEG and MRI.
  • ACG may offer a novel approach to supplement existing diagnostic strategies for sepsis-associated encephalopathy (SAE).